Prevention Of Radiodermatitis Research Articles

Photobiomodulation therapy for the prevention and treatment of acute radiation dermatitis in head and neck cancer: A case series

Objectiveto evaluate the effects of photobiomodulation therapy (PBMT) in the prevention of radiodermatitis in patients with head and neck cancer and to describes a protocol for the use of low-power laser with different energy doses according to the grades of acute radiation dermatitis (ARD). Methods and materialsThis is a case series study and were evaluated the medical records of 15 patients with head and neck cancer who underwent photobiomodulation for prevention and\\or treatment of ARD during radiotherapy treatment at São Luiz Jabaquara Hospital in São Paulo, from January 2021 to February 2022. The data obtained were organized in a descriptive way. ResultsOf the medical records eligible for the study, three were discarded because the patients did not undergo PBMT. These three evolved to grade III radiodermatitis and radiotherapy treatment was interrupted. Among sample receiving photobiomodulation therapy during radiotherapy treatment, 50 % developed radiodermatitis. 25 % presented grade I radiodermatitis and 25 % developed grade III radiodermatitis. However, only 1 % of the sample had its radiotherapy treatment interrupted due to radiodermatitis. ConclusionPhotobiomodulation is a safe and effective alternative in the management of radiodermatitis, but more studies are needed to establish a PBMT protocol.

Herbal Medicines for Treatment of Radiodermatitis: A Systematic Review and Meta-Analysis.

Background: There is some evidence in favor of the efficacy of herbal medicine in the treatment of radiodermatitis as a frequent complication among cancer patients. Purpose: The present study aimed to evaluate the effect of herbal medicines on the treatment of radiodermatitis in cancer patients. Study design: Systematic review performed in accordance with the PRISMA guideline. Methods: We searched the electronic databases, Scopus, PubMed, Cochrane Library, Embase, Google Scholar, and ISI Web of Science, through July 2020 for randomized controlled trials (RCTs) that compared herbal compounds against a standard medication or placebo for treatment or prevention of radiodermatitis. Results: A total of 16 RCTs involving 1886 patients with breast, head and neck, or unspecified cancer were included. Risk of bias generally was high. Of those, three RCTs with 562 cancer patients (mainly breast cancer) who used Aloe vera to treat radiodermatitis were included in the meta-analysis. There was a significant level of heterogeneity between the studies (I2 = 95.8). One RCT found positive effects of Aloe vera in reducing the severity of radiodermatitis (standardized mean difference [SMD] = 3.37), whereas another revealed an inverse effect (SMD = -4). Conclusion: At present, there are no herbal compositions that are effective in treating radiodermatitis, with Aloe vera failing to show sufficient efficacy in the meta-analysis.

Traditionally Used Natural Products in Preventing Ionizing Radiation-Induced.

In various traditional and folk systems of medicine, plants and plant products have been used since time immemorial for treating various skin ailments. Further, many cosmeceutical creams formulated based on knowledge from ethnomedicinal use are marketed and used to treat various ailments. In the current review, an attempt is made at summarizing the beneficial effects of some plants and plant products in mitigating acute radiation dermatitis in humans undergoing curative radiotherapy. Additionally, emphasis is also placed on the mechanisms responsible for the beneficial effects. The objective of this review is to summarize the clinical observations on the prevention of radiodermatitis by plant products. In this review, the protective effects of Adlay (Coix lachryma-jobi L.) bran extract, Aloe vera, Calendula officinalis, Cucumis sativus, green tea constituent the epigallocatechin-3-gallate, honey, Achillea millefolium, Matricaria chamomilla, olive oil, and some polyherbal creams are addressed by also focusing on the mechanism of action for the beneficial effects. Two authors' data mined for information in Google Scholar, PubMed, Embase, and the Cochrane Library for publications in the field from 1901 up to July 2020. The focus was on acute radiation dermatitis, ionizing radiation, curative radiotherapy, human cancer. The articles were collected and analyzed. For the first time, this review addresses the usefulness of natural products like adlay bran, Aloe vera, Calendula officinalis, Cucumis sativus, green tea constituent the epigallocatechin-3-gallate, honey, Achillea millefolium, Matricaria chamomilla, olive oil, and some experimentally constituted and commercially available polyherbal creams as skincare agents against the deleterious effects of ionizing radiation on the skin. The protective effects are possibly due to the free radical scavenging, antioxidant, anti-inflammatory, wound healing and skin protective effects. The authors suggest that these plants have been used since antiquity as medicinal agents and require in-depth investigation with both clinical and preclinical validated models of study. The results of these studies will be extremely useful to cancer patients requiring curative radiotherapy, the dermatology fraternity, agro-based and pharmaceutical sectors at large.

Comparative Evaluation of Topical Corticosteroid and Moisturizer in the Prevention of Radiodermatitis in Breast Cancer Radiotherapy.

Background:Radiodermatitis is a frequent side effect of breast cancer radiotherapy (RT). Treating radiation oncologist should know the prevention and treatment of every grade of radiodermatitis.Aims:The aim of this study was to compare the topical corticosteroid and moisturizer usage in breast cancer RT.Materials and Methods:Fifty patients with early-stage breast cancer undergoing breast-conserving surgery referred to our department for adjuvant RT between October 2009 and October 2016 were compared with regard to topical steroid or moisturizer usage. Patients were followed up weekly after the start of treatment.Results:Mean age was 46 years. Twenty-four patients had stage 1 breast cancer and 26 patients had stage 2 disease. KPS (Karnofsky performance score) was 100 for all patients. Five patients (20.8%) had grade 2 and seven (29.1%) patients had grade 1 acute radiodermatitis in the first group. Eleven (42.3%) patients had grade 2 and 12 (46.1%) patients had grade 1 acute radiodermatitis in the second group. Thirteen (54.1%) patients in the first group had no acute radiodermatitis and three (11.5%) patients in the second group had no acute radiodermatitis. No patient in either group experienced grade 3 radiodermatitis.Conclusions:Daily use of topical betamethasone for breast cancer RT improves dermal sparing, reduces acute radiodermatitis, and may be recommended for patients receiving RT to the breast.

Skin-related Quality of Life among Midwestern US Community-based Women with Breast Cancer Experiencing Radiodermatitis

Objective:Little is known about the skin-related quality of life (QOL) among women receiving external radiotherapy (EBT) and who experience breast radiodermatitis. This pilot study aimed to describe the thoughts and experiences of women experiencing breast radiodermatitis of the breast at a comprehensive community cancer program.Methods:A printed survey was used to solicit feedback on the Dermatology Life Quality Index (DLQI) during the 5th week of EBT. An open-ended question inquired which DLQI-related issue was most important and why. A directed qualitative content analysis was conducted on the narrative responses.Results:Twenty-eight women provided a response to the “most important” question. Sixty narratives led to the identification of 35 codes and six themes during content analysis. Themes included perspectives on having radiodermatitis, sensations caused by radiodermatitis, knowledge, and preparation for radiotherapy, prevention of radiodermatitis, emotions induced by skin changes, and physical appearance of the breast skin.Conclusions:The study results provide a glimpse into the perceptions of skin-related QOL among community-dwelling women who experienced breast radiodermatitis. Some women expressed that radiodermatitis had a profound impact on their QOL while other were surprised that EBT was easy compared to chemotherapy. Our findings parallel those found in a previous study conducted in an urban setting. Results provide insight into the thoughts and needs of women undergoing breast EBT. Assessing individual differences in skin-related QOL can provide needed information for tailoring care to the unique needs of each woman. Additional studies focusing specifically on skin-related QOL are needed.

Topical silymarin administration for prevention of acute radiodermatitis in breast cancer patients: A randomized, double-blind, placebo-controlled clinical trial.

Radiation-induced dermatitis is one of the most common side effects of radiotherapy. Silymarin, a flavonoid extracted from the Silybum marianum, exhibits antioxidant and anti-inflammatory activities. The purpose of this study was to investigate the efficacy of silymarin gel in prevention of radiodermatitis in patients with breast cancer. During this randomized, double-blinded, placebo-controlled clinical trial, the preventive effect of silymarin 1% gel was assessed in comparison with placebo, on radiodermatitis occurrence. Forty patients randomly received silymarin gel or placebo formulation on chest wall skin following modified radical mastectomy, once daily starting at the first day of radiotherapy for 5weeks. Radiodermatitis severity was assessed weekly based on Radiation Therapy Oncology Group (RTOG) and National Cancer Institute Common Terminology for Adverse Events (NCI-CTCAE) criteria radiodermatits grading scale for 5weeks. The median NCI-CTCAE and RTOG scores were significantly lower in silymarin group at the end of the third to fifth weeks (p value<0.05). The scores increased significantly in both placebo and silymarin groups during radiotherapy, but there was a delay in radiodermatitis development and progression in silymarin group. Prophylactic administration of silymarin gel could significantly reduce the severity of radiodermatitis and delay its occurrence after 5weeks of application.

Possible use of epigallocatechin-3-gallate (EGCG) as prevention of radio dermatitis in radiotherapy treated breast cancer patients

Dermatologic TherapyVolume 30, Issue 4 e12493 Letter to the Editor Possible use of epigallocatechin-3-gallate (EGCG) as prevention of radio dermatitis in radiotherapy treated breast cancer patients Massimo Bonucci, Massimo Bonucci Department of Nuclear Physics, Sub-Nuclear and Radiation, Guglielmo Marconi University, Rome, ItalySearch for more papers by this authorMassimo Fioranelli, Corresponding Author Massimo Fioranelli massimo.fioranelli@gmail.com orcid.org/0000-0002-1319-8779 Department of Nuclear Physics, Sub-Nuclear and Radiation, Guglielmo Marconi University, Rome, ItalyCorrespondence Massimo Fioranelli, Department of Nuclear Physics, Sub-Nuclear and Radiation, Guglielmo Marconi University, Rome, Italy. Email: massimo.fioranelli@gmail.comSearch for more papers by this authorMaria Grazia Roccia, Maria Grazia Roccia Department of Nuclear Physics, Sub-Nuclear and Radiation, Guglielmo Marconi University, Rome, ItalySearch for more papers by this authorTorello Lotti, Torello Lotti Department of Nuclear Physics, Sub-Nuclear and Radiation, Guglielmo Marconi University, Rome, ItalySearch for more papers by this author Massimo Bonucci, Massimo Bonucci Department of Nuclear Physics, Sub-Nuclear and Radiation, Guglielmo Marconi University, Rome, ItalySearch for more papers by this authorMassimo Fioranelli, Corresponding Author Massimo Fioranelli massimo.fioranelli@gmail.com orcid.org/0000-0002-1319-8779 Department of Nuclear Physics, Sub-Nuclear and Radiation, Guglielmo Marconi University, Rome, ItalyCorrespondence Massimo Fioranelli, Department of Nuclear Physics, Sub-Nuclear and Radiation, Guglielmo Marconi University, Rome, Italy. Email: massimo.fioranelli@gmail.comSearch for more papers by this authorMaria Grazia Roccia, Maria Grazia Roccia Department of Nuclear Physics, Sub-Nuclear and Radiation, Guglielmo Marconi University, Rome, ItalySearch for more papers by this authorTorello Lotti, Torello Lotti Department of Nuclear Physics, Sub-Nuclear and Radiation, Guglielmo Marconi University, Rome, ItalySearch for more papers by this author First published: 10 April 2017 https://doi.org/10.1111/dth.12493Citations: 2Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article.Citing Literature Volume30, Issue4July/August 2017e12493 RelatedInformation

Vitamin D ointment for prevention of radiation dermatitis in breast cancer patients

Radiation dermatitis occurs frequently during adjuvant radiation therapy for breast cancer. Prevention of radiation dermatitis by applying various creams and ointments has a limited success, and Aqua cream which has urea as one of its active ingredients is used in many institutions as a preventive treatment. The primary goal of this study is to assess the effect of vitamin D (calcipotriol) ointment in prevention of radiodermatitis in breast cancer patients compared to Aqua cream. Twenty-three women with localized breast cancer who underwent breast-conserving surgery and opted to receive adjuvant radiotherapy to breast only were enrolled in this study. A cream containing an active vitamin D analog, calcipotriol (Daivonex), was randomly applied either to the medial or to the lateral half of the irradiated breast, while Aqua cream was applied to the complimentary half of the same breast along the whole treatment days, each day, after the delivery of radiation. Skin reaction was recorded and compared between the two halves of the breast. Vitamin D was well tolerated by patients with no local or systemic allergic reactions. Radiation dermatitis was not significantly different between both treatment arms. Topical vitamin D ointment is not superior to Aqua cream for prevention of radiation-induced dermatitis in women treated with adjuvant radiation for breast cancer.

Implementing Evidence Based Practice in the Prevention of Radiodermatitis in an Outpatient Radiation Oncology Department

Radiation dermatitis is one of the most frequently observed acute side effects of radiation treatment. It can have a negative impact on quality of life and can cause delays in treatment. The current standard of care varies and is often based on anecdotal evidence. Most departments use a petroleum based gel. Calendula lotion is a less frequently recommended skin product. Is there recent research demonstrating significant effectiveness of calendula cream compared to petroleum based gel in decreasing radiation dermatitis to support a change in practice? A literature synthesis was completed. Picot question: among cancer patients who are undergoing radiation therapy, is treatment with a calendula lotion, as compared to treatment with a petroleum-based gel, less likely to have radiation dermatitis? There is some evidence that calendula is effective in reducing radiation dermatitis. It should be used in combination with skin cleansing, frequent assessments, and consistent education. There are many different calendula products on the market and personal preferences such as cost, availability, and ease of use should be considered with product recommendations. Patients should be informed that petroleum based gel does not cause harm, but there is no data to support any benefit. In addition, the Oncology Nursing Society lists calendula lotion as likely to be effective and petroleum based gel as effectiveness not established. Evidence pointed to a need to a change in practice. A power point presentation for nursing staff in the department of radiation oncology was completed to disseminate the findings of the literature review. Calendula lotions were recommended for use during treatment. Data was collected on patient preference of lotions used during radiation treatment including: effectiveness, ease of purchasing the product, cost, and ease of application. Twenty-one breast cancer patients undergoing daily radiation treatments were evaluated. Data was collected during weekly on treatment visit. The data collected found that all patients thought the calendula products were non-greasy and easy to apply. There was an 85% patient satisfaction with the lotion use on intact skin. A small % found the calendula products difficult to find and expensive. A new recommended skin care handout was completed, which included a list of products of various price ranges and where they could be purchased. Implications for practice: health care professionals can enhance patient care by providing education on evidenced based self-management measures. The change in practice on recommended skin care product resulted in 85% patient satisfaction and also promoted the use of evidence-based practice in radiation dermatitis.

Prevention of skin reactions due to teletherapy in women with breast cancer: a comprehensive review

One of the possible courses of cancer treatment is teletherapy, and one of the most important adverse side effects are skin reactions, an ailment more commonly called radiodermatitis. The main purpose of this study is to analyze knowledge of the evidence about topical products used in the prevention of radiodermatitis, to support care delivery to women with breast cancer during teletherapy. The research method used here is the comprehensive literature review. Four databases were used to select the bibliography. The sample consists of 15 articles. The data shows that, among the topical products analyzed here, Calendula, corticosteroids and Xclair have shown significant protective effects, underlining their actions. The lack of articles published in Brazil highlights the need for further research in this area, seeking better care quality through the use of products with scientifically proven efficiency.

Knowledge of nursing students about prevention of radiodermatitis

ABSTRACTObjective: to assess the knowledge of the last semester of the undergraduate nursing course students on prevention of radiodermatitis. Methods: this is about a cross-sectional study, from survey type. For data collection was applied a questionnaire for students of the 8th semester nursing course in four universities in Brasilia city. Statistical analysis was performed using the Statistical Package for Social Science, version 13.0. This study has been approved by the Committee of Ethics in Research of UNIEURO University Center (010/2008). Results: in a research with 52 students, of which have 44% reported the approach of cancer in some subjects during the course. When asked about the knowledge of prevention and treatment of radiodermatitis, except by students of the institution A, there was a good level of knowledge about the possible nursing interventions. Conclusion: the results suggest that the academics did not have sufficient knowledge of prevention of radiodermatitis caused by ionizing radiation in the treatment with radiotherapy. The training of nurses to prevent and treat the toxicities associated to cancer therapeutic modalities, especially in the study of radiodermatitis, which is more than essential, and the building up of this knowledge should start in the undergraduate course. Descriptors: cancer; radiotherapy; nursing care. RESUMOObjetivo: verificar o conhecimento de alunos do último semestre do curso de graduação em enfermagem sobre prevenção de radiodermatite. Métodos: trata-se de estudo seccional, tipo survey. Para a coleta de dados foi usado questionário aplicado aos alunos do 8º semestre do curso de enfermagem em quatro universidades de Brasília, após aprovação pelo Comitê de Ética em Pesquisa do Centro Universitário UNIEURO (010/2008). A análise estatística foi realizada com auxílio do Statistical Package for Social Science, versão 13.0. Resultados: participaram da pesquisa 52 estudantes, dos quais 44% referiram abordagem da oncologia em alguma disciplina no decorrer do curso. Quando questionados acerca do conhecimento sobre prevenção e tratamento da radiodermatite, exceto pelos alunos da instituição A, não houve bom nível de conhecimento sobre as possíveis intervenções de enfermagem. Conclusão: os resultados sugerem que os acadêmicos não possuíam conhecimento suficiente sobre prevenção de radiodermatite causada pela radiação ionizante no tratamento com radioterapia. Assim, a capacitação do enfermeiro para prevenir e tratar as toxicidades inerentes às modalidades terapêuticas oncológicas, destacando-se neste estudo a radiodermatite, é imprescindível, devendo a construção desse conhecimento iniciar ainda na graduação. Descritores: câncer; radioterapia; cuidados de enfermagem. RESUMENObjetivo: evaluar los conocimientos de los estudiantes del último semestre de la Escuela Universitaria de Enfermería en la prevención de Radiodermatitis. Métodos: es uma investigación transversal, tipo survey, por medio de un cuestionario aplicado a los estudiantes del 8º semestre del curso de enfermería en cuatro universidades de la ciudad de Brasilia. Este estúdio fue aprobado por el Comité de Ética em Investigación del Centro Universitario UNIEURO (010/2008). El análisis estadístico se realizó utilizando el Statistical Package for Social Science, version 13.0. Resultados: una búsqueda de 52 estudiantes, 44% informó obtener alguna informacion sobre el cáncer en algunas clase durante el curso de enfermeria. Cuando se les preguntó por el conocimiento sobre la prevención y el tratamiento de Radiodermatitis salvo por los estudiantes de la institución A, hubo buen nivel de conocimiento acerca de las posibles intervenciones de enfermería. Conclusión: los resultados sugieren que los académicos no tienen conocimientos suficientes sobre la prevención de Radiodermatitis causados por las radiaciones ionizantes en el tratamiento con radioterapia, por lo que la formación del personal de enfermería para prevenir y tratar la toxicidad asociada al cáncer de modalidades terapéuticas, especialmente en el estudio Radiodermatitis es esencial, y la construcción de este conocimiento debe iniciar en la graduación. Descriptores: cáncer; radioterapia; atención de enfermería.